Huijuan You

Mitochondria-Accumulating Nonplanar Perylene Diimides Suppress Mitochondrial DNA Transcription for Antitumor Therapy

Abstract Mitochondrial DNA (mtDNA) transcription is an emerging target in cancer therapy. While enzyme-targeted inhibitors like IMT1B block POLRMT, their organelle specificity remains unclear. Here, we report a distinct strategy using mitochondria-accumulating nonplanar perylene...