Hui Zhang

The NF-κB pathway in inflammatory responses in preeclampsia

Background: Preeclampsia is a pregnancy-specific hypertensive disorder associated with systemic inflammation, endothelial dysfunction, and adverse maternal and fetal outcomes. The nuclear factor kappa B (NF-κB) signaling pathway has been implicated in inflammatory activation, but...

Immune response to DNA and RNA: structural insights, molecular mechanisms, and therapeutic targeting

Abstract The recognition of mislocalized DNA and RNA by cGAS–STING, RIG-I/MDA5, the OAS–RNase L axis, and endosomal TLR3/7/8 has emerged as a unifying paradigm linking cancer, autoinflammation, and antiviral immunity. Counterbalancing these sensors is a structurally heterogeneous...