Hui Liang

Integrating bioinformatics and experiments to identify neddylation-related prognostic features in prostate adenocarcinoma

Targeting neddylation represents a promising treatment strategy for prostate adenocarcinoma (PRAD). This study integrated bioinformatics and experimental approaches to identify neddylation-related prognostic genes in PRAD, with the goal of providing new insights. Public datasets...

Pan-cancer screening and integrative multi-omics and deep learning reveal the prognostic significance of an IBD-CRC shared host–microbe signature in bladder urothelial carcinoma

Background The prognostic relevance of inflammatory bowel disease (IBD)–colorectal cancer (CRC) shared host–microbe signatures in non-intestinal epithelial malignancies remains unclear. This study aimed to evaluate the prognostic and biological significance of an IBD-CRC shared h...

YAP delactylation enhances therapy resistance in renal cell carcinoma

Abstract Lactylation is a novel lysine acylation modification, and its function and exact mechanisms remain unclear. The responsiveness to combined targeted and immunotherapy continues to be a major challenge in cancer treatment. Here, we discovered that lysine lactylation (Kla)...