Hugo Granchetti

Core protein mutations are key determinants of hepatitis B virus replication during the hepatitis B e antigen-negative stage

The natural history of chronic hepatitis B virus (HBV) infection comprises distinct stages resulting from virus–host interactions. A late and pivotal event in this process is hepatitis B e antigen (HBeAg) seroconversion, marked by the abrogation of HBeAg expression, a significant...