Hugh David Piggins

Conserved circadian membrane rhythms arise from divergent cellular mechanisms in pacemaker neurons of mice and Drosophila

Abstract Circadian clocks align physiology and behaviour with daily environmental cycles, requiring neuronal networks that encode and transmit time-of-day information. Whether conserved electrophysiological principles underlie circadian output across evolution remains unclear. We...

Meal timing entrains circadian rhythms in the dorsal vagal complex, a brainstem satiety centre

The dorsal vagal complex (DVC) includes a multi-component brainstem satiety centre which has gained attention as a key target of anti-obesity pharmacotherapies. Our recent studies revealed its circadian timekeeping properties, with molecular and electrophysiological 24 h rhythms...