Huangxuan Zhao

Metabolic reprogramming of macrophage-specific transketolase orchestrates angiogenesis in diabetic wounds

Diabetic wound healing is profoundly impaired by macrophage metabolic dysfunction, which compromises angiogenesis. Here, we show a macrophage transketolase (TKT) as a crucial metabolic checkpoint governing vascular regeneration in diabetes. We demonstrate that loss of TKT in macr...