Huan Liu

PTTG1-driven self-amplifying loop with SP1 and ENO1 promotes IRF4-mediated myeloma progression and bone destruction

Abstract Multiple myeloma (MM) is a neoplastic disorder of plasma cells within the hematopoietic system and is characterized by osteolytic lesions. Despite significant advances, the molecular underpinnings of myeloma and its associated bone pathologies remain elusive, and there i...

Adipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma

Multiple myeloma (MM) remains an incurable blood cancer. Obesity is a known risk factor, but how adipocytes promote MM progression is not fully understood. Here, we uncover a metabolic crosstalk between adipocytes and MM cells that promotes MM cell survival under glucose deprivat...