Hualong Chen

First-In-Human PET Imaging of Synaptic Vesicle Glycoprotein 2A with [18F]BIBD-181: Automation, Biodistribution, Dosimetry, and Preliminary Application in Epilepsy

Abstract We report the first-in-human evaluation of [18F]BIBD-181, a novel SV2A tracer designed with a fluoropropyl side chain to enable mild, automated radiosynthesis. A fully automated cGMP-compliant production process was developed on a commercial synthesizer, yielding the tra...

AIS-Based Forecasting of STEAM-Estimated Ship CO2 Emissions for Sustainable Maritime Transportation Using a Spatio-Temporal Graph Transformer

Accurate short-horizon forecasting of ship CO2 emissions is important for maritime carbon monitoring, operational assessment, and the transition toward sustainable maritime transportation. However, reliable forecasting remains challenging because ship emissions are affected by te...