Hsiaochi Chang

Simultaneous Measurement of Total and Occupied/Free PD-1 on a Single Cell by Mass Cytometry: Development of a Novel Method for Receptor Occupancy Assessment

Receptor occupancy (RO) assays are often used to quantify and characterize the binding profiles of antibody-based therapeutic drugs to target receptors, providing valuable pharmacodynamic insights. Programmed cell death protein 1 (PD-1) is a key immune checkpoint that suppresses...