Hristo L. Svilenov

Becoming the bull : Structural insights and engineering strategies for ultralong CDR ‐ H3 paratopes from cattle

Cattle produce a subset of antibodies (Abs) with unique architecture. These immunoglobulins feature an ultralong CDR-H3 (uCDR-H3) composed of up to about 70 amino acids that protrudes from the scaffold and folds into a distinct stalk-and-knob structure. The knob is a disulfide-ri...