Hossein Rafiei

Berberine as a Mitochondrial Metabolic Reprogrammer in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Adaptive Energetic Stress, Quality Control, and Translational Limitations

Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely linked to mitochondrial dysfunction, including altered oxidative phosphorylation, disrupted fatty-acid oxidation, redox imbalance, abnormal mitochondrial dynamics, and impaired quality control. Berberine...

Synergistic effects of Tschimgine combined with 5-Fluorouracil against HT-29 human colorectal cancer cells

Colorectal cancer (CRC) represents a leading cause of cancer morbidity and mortality globally. Tschimgine (Tsc), a naturally occurring terpenoid from Ferula ovina , has exhibited potent anticancer activity in preclinical models. However, its ability to enhance the sensitivity of...