Hossein Mohammad‐Beigi

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

ABSTRACT Aggregation of α‐synuclein (αSyn) is a hallmark of Parkinson's disease, yet its pathological roles remain poorly understood. Elucidating these roles requires detailed knowledge of the free energy landscape of αSyn self‐assembly, i.e. the states that can be populated and...

Localized brain delivery of drugs via focused ultrasound-responsive bi-layer nanobubbles

Focused ultrasound (FUS) in combination with micro- or nanobubbles is a promising strategy for transiently and non-invasively opening the blood-brain barrier (BBB) to enable targeted drug delivery to the brain. Here, we report a FUS-responsive delivery system using bi-layer nanob...