Hossein Esfahani

Dual topical therapy with doxepin and allopurinol mouthwash for severe methotrexate-induced oral mucositis: a pediatric case report

High-dose methotrexate (HD-MTX) is a cornerstone of chemotherapy for pediatric osteosarcoma but frequently induces severe oral mucositis, a dose-limiting toxicity characterized by painful ulceration and impaired oral function. While standard supportive care includes leucovorin re...