Hongzhao Lu

Leptin attenuates heat stress-induced mitoxyperilysis in porcine Sertoli cells by suppressing the mtDNA-cGAS-STING axis

Abstract Background Mammalian spermatogenesis is highly temperature-sensitive and relies critically on the protective function of Sertoli cells. Although heat stress is known to affect Sertoli cell fate, it remains unclear whether it triggers mitoxyperilysis and by what mechanism...