Hongyu Bao

Shared‐Output Aptamer‐Gated DNA Nanodevices Program NbaSPARDA Trans‐Cleavage for Metabolite and Drug Sensing

ABSTRACT Routing chemically distinct small‐molecule aptamers into a common nuclease trans‐cleavage pathway is constrained by the target‐specific output handles of conventional structure‐switching aptamers (SSAs). Shared‐output aptamer‐gated DNA nanodevices are designed so that re...