Hongwu Yang

Structural and mechanistic basis of selective inhibition of the fungal‐specific histone deacetylase Hos3 from the pathogenic fungus Aspergillus fumigatus

Histone deacetylases (HDACs) are critical epigenetic regulators of fungal growth and pathogenicity and constitute promising targets for antifungal drug development. Hos3 defines a fungal-specific HDAC subclass that lacks a clear mammalian ortholog; however, the structural determi...