Hongmiao Yao

Discovery of Novel Pyrazole-4-Carboxamide and Aromatic Carboxamide Derivatives Containing a Trans-2-(Trifluoromethyl)cyclopropyl Moiety as Potential SDHIs

Abstract A series of racemic pyrazole-4-carboxamide and aromatic carboxamide derivatives bearing a trans-2-(trifluoromethyl)cyclopropyl moiety were designed and synthesized as potential succinate dehydrogenase inhibitors (SDHIs). The compounds were evaluated for their in vitro an...