Hongmei Cao

ProgrammableVersatile Socket: A Tight-Locking andHigh-Gain CRISPR/Cas12a Molecular Circuit for Ultrasensitive Sensingof Diverse Targets

Abstract CRISPR/Cas12a has emerged as an important platform for nucleic acid analysis, yet limited catalytic turnover and intrinsic nucleic acid specificity constrain its sensitivity and analyte scope. Herein, a tight-locking and high-gain Cas12a-driven strand displacement amplif...