Hongli Yu

Dual Regulation of ACSL3 by TRIM33-Mediated Ubiquitination and NBR1-Dependent Autophagy: A Therapeutic Target for Cerebral Ischemia-Reperfusion Injury

Background: Cerebral ischemia-reperfusion injury (CIRI) is a key contributor to stroke-related neurological damage, but the functional interplay between autophagy and ferroptosis—two critical pathological processes—remains poorly understood. Methods: Using oxygen-glucose deprivat...

Atomically Precise Pt 3 Cu 2 Clusters Restore Energy Metabolism via Targeted Succinate Degradation

ABSTRACT Succinate is a critical intermediate for the tricarboxylic acid cycle, whose abnormal accumulation can disrupt energy homeostasis and trigger systemic inflammatory injury across dominant metabolic organs. Targeting succinate thus represents a pivotal strategy to reestabl...