Honglan You

Highly Sensitive Electrochemical Biosensing Strategy Based on Multiple CRISPR/Cas12a Trans -Cleavage Units

Abstract This study presents the assembly of multiple CRISPR/Cas12a units by target-induced hybridization chain reaction (HCR), which is capable of highly sensitive electrochemical detection of target miRNA. The confinement effect of the HCR/Cas12a system is demonstrated, which s...