Hongkun Wang

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

ABSTRACT Extracellular pore domains of ion channels are emerging as dynamic regulatory surfaces, but whether they can be rationally targeted to achieve selective channel modulation remains unclear. Here, using an optimized hotspot‐centric design strategy, we developed Depiv2, a s...