Hongjun Xiao

Non-Destructive Chemoselective Labeling and Bioorthogonal Enrichment of Pseudouridine-Containing RNA via Facile N 1-Selective Functionalization

Abstract Pseudouridine (Ψ), often referred to as the “fifth nucleotide”, constitutes the most abundant post-transcriptional RNA modification and plays pivotal roles in regulating RNA structure and function. However, the precise mapping and functional investigation of Ψ remain cha...