Hongjin Chen

Intrinsic capacity, genetic susceptibility and incident inflammatory bowel disease: a prospective cohort study in UK Biobank

Abstract Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder, but whether intrinsic capacity (IC), a multidomain measure of functional reserve, is associated with incident IBD remains unclear. We analysed 427,489 UK Biobank participants free of IBD at baseline...

Batatasin III alleviates inflammatory bowel disease by suppressing MMP7 and NFκB signaling in macrophages and restoring gut microbial balance

Inflammatory bowel disease (IBD), comprising Crohn’s disease and ulcerative colitis, is characterized by chronic intestinal inflammation, disruption of the mucosal barrier, and immune dysregulation. Recent evidence underscores the role of gut macrophages, microbiota, and proinfla...