Honghe Zhang

Interplay of neuropeptide Y, metabolic dysfunction, and inflammation in cognitive impairment of major depressive disorder: a sex-stratified study

Abstract Background Major depressive disorder (MDD) is associated with metabolic disturbances (elevated TyG index), peripheral inflammation (IL-6, TNF-α, CRP), and cognitive deficits. Serum NPY levels vary by sex and reproductive aging, influencing appetite changes in MDD. Howeve...