Hongguo Han

Novel cocrystal inclusion compound of bezafibrate with L-proline: preparation, characterization and in vitro/in vivo evaluation

OBJECTIVE: To improve the solubility and dissolution of bezafibrate (BEZA) and enhance its bioavailability. SIGNIFICANCE: BEZA has poor solubility. This study has solved this limitation through a novel cocrystal-inclusion compound strategy. METHODS: The cocrystal of BEZA and L-pr...