Hongbo Zhou

Genomic and pathogenic characterization of a chicken-origin cluster 3.2 Tembusu virus isolated in China

Abstract Tembusu virus (TMUV) is an emerging flavivirus that causes encephalitis and a decrease in egg production in poultry across East and Southeast Asia. Here, we isolated and characterized a chicken-origin TMUV strain, CHN-WH, from a laying hen farm in China. Whole-genome seq...

MutFormer: a multimodal deep learning framework for predicting somatic mutation hotspots from sequence and chromatin features

Somatic mutations are unevenly distributed across the genome, with certain loci recurrently mutated across independent tumors. Both local DNA sequence context and chromatin organization have been associated with mutation rate variation, yet their combined effects at single-nucleo...