Hong Tang

Targeting GGT1 via RGD-modified lipid nanoparticles suppresses breast cancer lung metastasis by disrupting exosome-mediated angiogenesis

Breast cancer lung metastasis remains a major cause of mortality, largely because effective treatment options are limited. In this study, we identify gamma-glutamyltransferase 1 (GGT1) as a factor associated with breast cancer lung metastatic progression. Analyses of clinical dat...

Atractylodis Rhizoma-derived nanovesicles suppress adipocyte IDO1/kynurenine-AhR-androgen receptor signaling in a mouse model of obesity-associated PCOS

Abstract Background Obesity-associated polycystic ovary syndrome (PCOS) is characterized by metabolic dysfunction, adipose inflammation and androgen excess, but the adipose mechanism linking metabolic stress to androgen-related pathology remains unclear. This study aimed to deter...