Holger Frey

Effective Reductionof Anti-PEG Antibody Recognitionvia PEG Copolymers with Ethyl Glycidyl Ether and Isopropyl GlycidylEther

Abstract Anti-PEG antibodies (APAs) lead to accelerated blood clearance of PEGylated drugs and nanocarriers. Randomized PEG (rPEG) reduces APA recognition by randomly incorporating glycidyl methyl ether in PEG. Extending this concept, statistical copolymerization of ethylene oxid...