Hitomi Matsuzaki

Two distinct domains in mouse IG-DMR of the Dlk1–Dio3 locus confer imprinted DNA methylation in transgenic mice

Abstract Faithful maintenance of allele-specific methylation at imprinting control regions (ICR) is essential for genomic imprinting. Using transgenic mice (TgM), we investigated sequence requirements for paternal methylation acquisition and maternal hypomethylation maintenance d...