Hisato Kawakami

Potential utility of more subtle microsatellite instability for predicting response to nivolumab in gastric cancer patients

The relationship between microsatellite instability (MSI) - high (H) and deficient DNA mismatch repair is, in fact, not straightforward. MSI observed in genome-edited cells carrying Lynch syndrome mutations is not so drastic as in typical MSI-H ( i.e. Type B mode) but uniformly m...