Hirotaka Yonezawa

Molecular Mechanisms Underlying Progression and Spontaneous Regression in Desmoid Tumors

Desmoid-type fibromatosis, also known as desmoid tumor (DT), is a rare and locally aggressive soft tissue neoplasm driven by constitutive activation of the Wnt/β-catenin signaling pathway, most commonly through CTNNB1 or APC alterations. While some tumors progress and cause subst...