Hiroshi Sakamoto

Bottom-Up Model Suggesting Membrane Localization of Heme Oxygenase-1 Contributes to Heme Selection for Degradation

Abstract Heme functions as a prosthetic group in numerous hemoproteins, whereas a fraction of intracellular heme is not tightly bound to proteins or membranes and can readily dissociate; this labile heme participates in the regulation of diverse cellular processes. Heme has pro-o...