Hiroshi Hanafusa

Astrocytic cathepsin D promotes α-synuclein processing and Lewy neurite-like aggregate maturation

Abstract Parkinson’s disease (PD) and related synucleinopathies are marked by the accumulation and propagation of α-synuclein (α-syn) aggregates, a process primarily studied in neurons. Whether astrocytes actively contribute to α-syn processing and intercellular transfer remains...