Hironobu Hojo

Mining of NovelHuman DPP-IV-Targeting Tripeptidesthrough Multicomputational Screening and In Vitro Validation for DiabetesTherapy

Abstract Inhibition of human dipeptidyl peptidase IV (hDPP-IV) is considered an effective strategy in the management of type 2 diabetes (T2D). However, the lack of high-throughput screening approaches and the high cost of experimental evaluation have limited the discovery of pept...

No Significant Secondary Structural Change of α‐Synuclein Monomer by Site‐Specific DOPA or Phosphorylation Introduction in Its C‐Terminal Region

ABSTRACT α‐Synuclein (αSyn) is a major component of pathogenic Lewy bodies and Lewy neurites and is closely associated with Parkinson's disease. Among the various posttranslational modifications of αSyn, several have been implicated in the degeneration of dopaminergic neurons and...