Hiromitsu Shirasawa

Central spindle instability and ectopic furrow organization mark fragmentation-prone first mitosis in human embryos

Abstract Severe cell fragmentation compromises blastocyst formation and correlates with aneuploidy, but the mitotic events associated with fragmentation remain unclear. Using non-invasive live-cell imaging of DNA, tubulin, and/or actin in discarded human two-pronuclear embryos, h...