Hiroki Hayashi

Intramolecular Hydride Transfer Racemization Coupled with Enzymatic Kinetic Resolution Enables Asymmetric Syntheses of Caged Compounds

Abstract Caged molecules featuring the pentacycloundecane framework and related substructures represent an exciting class with numerous potential applications, yet reports of their asymmetric syntheses are scarce. In this work, we report a method for the asymmetric synthesis of t...

Visualizing electron flow at transition states by natural reaction orbitals

Transition-state analysis in quantum chemistry provides structural and energetic information but does not directly reveal how electron density is redistributed at the onset of bond reorganization. Although frontier-orbital theory is highly effective for predicting reactivity from...