Hirofumi Takano

Dabrafenib plus trametinib in BRAF V600E-mutant Erdheim–Chester disease: a case series including CNS involvement

Abstract Background Erdheim–Chester disease (ECD) is a rare clonal non-Langerhans cell histiocytosis characterized by the infiltration of foamy, CD68-positive/CD1a-negative histiocytes into multiple organ systems. Activating MAPK/ERK pathway mutations, most commonly BRAF V600E, r...