Hirofumi Chiba

Long-term outcomes of upfront combination therapy for PPF: TOP-ILD phase 2 study

Background Progressive pulmonary fibrosis (PPF) has a poor prognosis, with optimal treatment strategies remaining undefined. We previously reported favorable 24-week outcomes with upfront triple combination therapy (nintedanib, tacrolimus, prednisolone) in treatment-naïve PPF pat...

Altered balance between circulating T follicular helper and T peripheral helper cells and regulatory B cells in COPD: an exploratory cross-sectional study

Abstract Background Tertiary lymphoid organs (TLOs) develop in the lungs of patients with chronic obstructive pulmonary disease (COPD) and may contribute to persistent inflammation. CXCL13 is involved in lymphoid follicle organization, but the relationships among circulating T fo...