Hideaki Nakamura

Tumor-SelectiveVascular Modulation by Acid-CleavableRetro-Inverso Bradykinin Conjugates Enhances the Antitumor Efficacyof Nanomedicine

Abstract Enhancing the tumor accumulation of nanomedicines through vascular modulation represents a promising strategy to improve anticancer drug delivery. Bradykinin (BK), a potent vasoactive peptide, can enhance intratumoral blood flow and vascular permeability; however, its cl...