Hesham N. Mustafa

Dose-Dependent and Route-Modulated Gastric Mucosal Injury Induced by Acrylamide: Histological, Ultrastructural, and Morphometric Evidence

Abstract Objective: Acrylamide is a heat-generated food contaminant, but its effects on distinct gastric epithelial cell populations remain incompletely characterized. The aim of this study was to determine whether acrylamide administered for 10 consecutive days at 25 or 50 mg/kg...

Circulating Hepatocyte Nuclear Factor-4α is Associated with Metabolic Dysfunction and Hepatic Remodeling in Fructose-Induced Metabolic Syndrome: An Immunomorphometric Study

Metabolic syndrome (MS) driven by excessive dietary fructose is associated with progressive hepatic injury including steatosis, inflammation, fibrosis, and apoptosis. Hepatocyte nuclear factor-4α (HNF4α), a master transcriptional regulator of hepatic metabolism, is typically down...