Hesham N. Mustafa

Circulating Hepatocyte Nuclear Factor-4α is Associated with Metabolic Dysfunction and Hepatic Remodeling in Fructose-Induced Metabolic Syndrome: An Immunomorphometric Study

Metabolic syndrome (MS) driven by excessive dietary fructose is associated with progressive hepatic injury including steatosis, inflammation, fibrosis, and apoptosis. Hepatocyte nuclear factor-4α (HNF4α), a master transcriptional regulator of hepatic metabolism, is typically down...