Herman P. Spaink

TLR Signaling Beyond Immunity: Emerging Roles in Cell Migration, Metabolism, Development, and Host–Microbiome Crosstalk

Recent findings support a broader view of TLR signaling as an integrative signaling hub that links immunity with cell migration, metabolism, development, and host–microbiome crosstalk. In cell migration, TLRs exert context-dependent effects through chemokine receptor regulation,...

A modern toolbox to elucidate the role of the human microbiome in modulating mycobacterial gut infections

Abstract Inflammatory bowel diseases (IBDs) are a major public and veterinary health concern, but the causes are poorly understood. In this review, we discuss the potential of mycobacteria as causative factors for such diseases. We focus on similarities between the most common hu...