Henry Markram

An interpretable deep learning framework for classifying neuronal morphologies using topology and graph neural networks

Abstract Neuronal shape determines how neurons process and integrate information, yet a consistent and objective classification of neuronal morphologies remains elusive. Current approaches rely heavily on subjective expert views or on predefined features, limiting reproducibility...

Temperature dependence of HCN channel kinetics: A systematic comparison across mammalian isoforms and species

Abstract Hyperpolarization‐activated, cyclic nucleotide‐gated (HCN) channels are important regulators of cardiac pacemaking and neuronal excitability, yet their temperature dependence has not been compared systematically across mammalian isoforms and species in standardized exper...