Henrikas Paužas

IL1B rs1143634 genotype and differential cancer-specific survival by neoadjuvant strategy in locally advanced rectal cancer: an exploratory analysis of a prospective randomized noninferiority trial

Abstract Background Locally advanced rectal cancer (LARC) treatment selection between neoadjuvant intensified chemotherapy (NIC) and standard chemoradiotherapy (CRT) lacks validated predictive biomarkers. Interleukin-1β (IL1B) polymorphisms modulate IL-1β expression and may influ...

Altered contractile responses to angiotensin II and cholinergic stimulation in colonic circular smooth muscle from patients with diverticular disease

Background Abnormal circular smooth muscle contractility is considered a key factor in the pathogenesis of diverticular disease (DD), contributing to increased intraluminal pressure and diverticulum formation. Altered cholinergic responsiveness of colonic smooth muscle has previo...