Heng Jiang

Asymmetric Radical-Type Clayden Rearrangement for the Synthesis of Enantiopure 1,2-Aminothiols and 1,2-Aminoalcohols

Abstract We report herein an expedient method for the construction of enantiopure 1,2-aminothiols and 1,2-aminoalcohols starting from polar amino acids cysteine and serine via a photoredox-catalyzed, decarboxylation-enabled asymmetric radical-type Clayden rearrangement. The strat...