Hema Chandra Kotamarthi

Topologically complex knotted proteins are processed differentially by ATP ‐dependent proteases ClpXP and ClpAP

Abstract Knotted proteins can present a distinct topological and mechanical challenge to the AAA+ cellular degradation machineries, determined by the relative size of the knot and the pore dimensions of these enzymes. In this study, we investigated the degradation mechanism of kn...