Helena Radbruch

Human hair–bearing skin organoids reveal cell type–specific susceptibility and innate immune responses to herpes simplex virus 1

Epithelial surfaces are the primary sites of lytic herpes simplex virus 1 (HSV-1) infection following initial exposure or reactivation from latency. To model this complex environment, we used human hair–bearing skin organoids and combined single-cell spatial transcriptomics with...

Astrocytic EAAT ‐2 Upregulation Supports Neuro‐Axonal Homeostasis in Chronic Inflammatory CNS Lesions

ABSTRACT Neuronal loss in multiple sclerosis (MS) is a key factor in the progression of disability. Axonal degeneration within MS lesions is central to progressive MS pathology, yet its mechanisms are not fully understood. Excess extracellular l‐glutamate (GLUT) is neurotoxic due...