Helena Kupcová Skalníková

FAP+ pericyte-like cells promote monocyte differentiation into tumor-associated macrophages in glioblastoma

Abstract Glioblastoma (GBM) is a highly aggressive primary brain tumor characterized by profound immunosuppression that facilitates tumor progression and promotes therapeutic resistance. Fibroblast activation protein (FAP), a recognized theranostic target in multiple cancers, is...

PIWIL2 contributes to glioblastoma stem cell phenotypes

Abstract PIWI proteins, a conserved Argonaute subfamily of proteins that interact with PIWI-interacting RNAs (piRNAs), have been implicated in cancer development. However, their roles in glioblastoma (GBM), particularly in glioblastoma stem cells (GSCs), a therapy-resistant subpo...