Helen H. Hobbs

Structure and function of TM6SF1 reveals role in mTORC1 signaling

The transmembrane 6 superfamily (TM6SF) comprises two members: TM6SF1, a ubiquitously expressed lysosomal membrane protein of unknown function, and TM6SF2, an endoplasmic reticulum protein required for bulk lipidation of Apolipoprotein B–containing lipoproteins. Here, we used cry...