Helen Azer

HSP70 as a Host-Directed Target for Broad-Spectrum Antivirals Against Emerging WHO Priority Viruses

The development of broad-spectrum antivirals remains a major challenge in global health, as most existing antiviral drugs target virus-specific proteins and are therefore ineffective against unrelated viruses. As emerging and re-emerging viruses prioritized by the World Health Or...

Molecular Weight-based Concentration and Ni-NTA Enrichment Enhance Detection of OmpT-cleaved BrkA Passenger Domain in the Extracellular Milieu of Escherichia coli UT2300

Autotransporter secretion systems are used by Gram-negative bacteria to transport proteins across the cell envelope. Bordetella resistance to killing protein A (BrkA) is an autotransporter protein in Bordetella pertussis whose passenger domain remains non-covalently associated wi...