Hélcio Silva dos Santos

Integrated quantum chemical calculations and in silico approach to the anxiolytic effects of campesterol and its derivatives, with evaluation of locomotor activity in adult zebrafish (Danio rerio)

Abstract In this study, the anxiolytic and locomotor activity of campesterol and its seven derivatives were evaluated. The tests were analyzed using the zebrafish ( Danio rerio ) model. The animals were treated intraperitoneally ( i.p .) with the samples (4, 20, and 40 mg/kg in 2...

Hydrogel-based strategies for the controlled delivery of analgesic and anti-inflammatory drugs

Abstract In clinical practice, drug encapsulation is an important strategy for enhancing therapeutic efficacy and reducing adverse effects. This review critically examines how polymer origin, crosslinking strategy, swelling behavior, degradation rate, and three-dimensional networ...